Tracking the scale-up challenge of precision fermentation — from lab-scale proof of concept to commercial production. The critical question: can biology compete with petrochemistry and animal agriculture on COGS?
| Company | Product | Chassis | Scale | Stage | Funding |
|---|---|---|---|---|---|
| Perfect Day | Whey protein | Trichoderma reesei | 50,000L | Commercial | $750M+ |
| Solugen | Industrial chemicals | Chemienzymatic | Bioforge (commercial) | Commercial | $400M+ |
| LanzaTech | Ethanol from CO/CO2 | Clostridium autoethanogenum | Commercial plants | Commercial | Public (LNZA) |
| Synonym | Biomanufacturing infra | Platform-agnostic | Capacity broker | Commercial | $120M+ |
| Pow.bio | Contract biomanufacturing | Multi-organism | 200,000L+ | Commercial | $30M+ |
| Bolt Threads | Mylo (mycelium leather) | Mycelium | Pilot | Pilot | $213M |
| MycoWorks | Reishi (fine mycelium) | Mycelium | Commercial | Commercial | $187M+ |